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Getting pregnant with Polycystic Ovary Syndrome (PCOS) is difficult but not impossible. Women with PCOS have an excess of male hormones or androgens. An excess of male hormones causes an imbalance of hormones, such as estrogen, which are needed for reproduction. At the root of this hormonal imbalance is a condition named insulin resistance. Dealing with hormonal imbalance requires holistic changes to your diet and lifestyle. Once the underlying hormonal imbalance is fixed, it is very much possible to get pregnant with PCOS.