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Fight Diabetes Caused By Statins with CoQ10 Supplements

Fight Diabetes Caused By Statins with CoQ10 Supplements

Been taking statins to lower your blood cholesterol? You need to be aware of concerns around statins increasing the risk of diabetes. Let’s understand the connection and the role of CoQ10 supplementation in dealing with this risk.

Statins: The Basics Explained

For those who are not aware, statins are drugs taken by those at a risk of heart disease and have high LDL-cholesterol and C-reactive protein levels. They reduce LDL (low-density lipoproteins are a primary constituent of plaque that collects in the arteries) and C-reactive proteins (substances whose levels escalate with the presence of inflammation) in the blood. C-reactive proteins are important predictors of a possible cardiovascular event, such as a stroke or myocardial infarction. But, what’s the connection between statins and diabetes? Let’s find out.

How Statins Can Lead To Diabetes?

The function of insulin in the body is an important one as its secretion and absorption by the cells (sensitivity and resistance levels) determine whether, or not, one might suffer from diabetes.

Statins impair insulin secretion as well as reduce the sensitivity of fat cells to insulin.

This occurs because they cause the following reactions:

  • They disrupt the mechanism by which insulin particles are exchanged across the pancreatic beta-cell membrane.
  • They reduce the number of GLUT4 glucose-transporters that carry glucose into adipocytes (fat cells).

Statins also make your muscles ache and make you feel fatigued, reducing your motivation to exercise. Thus, they increase your propensity to develop visceral fat or fat around your internal organs. This condition is known as sarcopenia, or being thin-outside-fat-inside, and is linked to glucose intolerance and Type 2 Diabetes.

How Co Q10 Helps In Fighting Statin-Induced Diabetes?

Statins bring down the secretion of beneficial substances, such as CoQ10, which are released naturally when cholesterol is synthesized. Statins block a precursor of CoQ10, which is a critical ingredient in the production of adenosine triphosphate (ATP), an energy-carrying molecule, generated by cells.

Also, in general, diabetics are known to have low levels of CoQ10 because a lot of it is used in combating oxidative stress caused due to their illness. Reduced levels of CoQ10 lead to delays in the generation of ATP, making the mitochondria dysfunctional. This dysfunction, particularly in skeletal muscle cells, adipocytes and pancreatic beta cells, results in high glucose levels.

Supplementing with the right amount of CoQ10 can help in dealing with statin-induced diabetes. For most people, 200 mg a day of CoQ10 supplementation works. Please consult your doctor to find out the exact dosage for your needs.

Sharda Agarwal

Sharda Agarwal

Co-founder, Sepalika. Nutritional Therapy Practitioner (Cert Awaited), Nutritional Therapy Association, USA
Sharda Agarwal is a qualified Functional Nutrition Therapy Practitioner. She first used dietary supplements to overcome a debilitating migraine she suffered for years. Since then she has studied the subjects of nutrition and nutrients extensively. She uses this to manage the health of her family at home and with Sepalika.
Sharda Agarwal

Latest posts by Sharda Agarwal (see all)

Aiman, U., Najmi, A., & Khan, R. A. (2014). Statin induced diabetes and its clinical implications. Journal of Pharmacology and Pharmacotherapeutics, 5(3): 181-185.

Carter, A. A., Gomes, T., Camacho, X., Juurlink, D. N., Shah, B. R., & Mamdani, M. M. (2013). Risk of incident diabetes among patients treated with statins: population based study. BMJ.

D, P., SR, S., P, W., SA, M., JE, H., DD, W., . . . KK, R. (2011). Risk of incident diabetes with intensive-dose compared with moderate-dose statin therapy: a meta-analysis. JAMA, 305(24): 2556-64.

DC, C., J, P., & GF, W. (2015). Pathogenesis and management of the diabetogenic effect of statins: a role for adiponectin and coenzyme Q10? Current Atherosclerosis Report, 17(1): 472.

Rajpathak, N., S., Kumbhani, D. J., Crandall, J., Barzilai, N., Alderman, M., & Ridker, P. M. (2009). Statin therapy and risk of developing type 2 diabetes: a meta-analysis. Diabetes Care, 1924-1929.

Ridker, e. a. (2008). Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein. The New England Journal of Medicine, 359:2195-2207.

Shen, Q., & Pierce, J. D. (2015). Supplementation of Coenzyme Q10 among Patients with Type 2 Diabetes Mellitus. Healthcare (Basel), 3(2): 296-309.

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This article is intended for informational purposes only. The content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. strongly recommends that you consult a medical practitioner for implementing any of the above. Results may vary from person to person.

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